Figure 4

Rapamycin treatment of Rosa-FRB^PLF/CGRP-Inp54p mice did not affect hypersensitivity following inflammation. A-C) Control experiments with CGRP-Inp54p^+/− mice. A) Edema, B) noxious thermal hyperalgesia and C) mechanical allodynia following intraplantar injection of CFA. No significant differences between genotypes before or after CFA injection. n = 12 male mice per genotype. D-F) Rosa-FRB^PLF/CGRP-Inp54p double heterozygous mice. D) Edema, E) noxious thermal hyperalgesia and F) mechanical allodynia following intraplantar injection of CFA. Black arrows indicate i.t. rapamycin (1 nmol) injections, red arrows indicate intraplantar CFA injection. No significant differences between genotypes before or after CFA injection. n = 10 male mice per genotype.