Table 6 Effect modification by type 2 diabetes on the association between NGFR haplotypes and the risk of Alzheimer's disease stratified by ApoE ε4 status
From: Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease
| Â | NGFR variant non-carriers | NGFR variant carriers | P interaction | ||
|---|---|---|---|---|---|
| Â | Case/control | OR | Case/control | OR (95%CI) | Â |
ApoE ε 4 non-carriers |  |  |  | ||
   Hap1: GCGCG |  |  |  |  |  |
Diabetes | 23/23 | 1.00 | 8/21 | 0.28 (0.08-0.97) | Â |
Without diabetes | 64/151 | 1.00 | 60/134 | 0.90 (0.53-1.51) | 0.12 |
   Hap2: GCTTG |  |  |  |  |  |
Diabetes | 15/29 | 1.00 | 17/15 | 2.79 (0.83-9.43) | Â |
Without diabetes | 83/173 | 1.00 | 41/112 | 0.73 (0.42-1.26) | 0.04 |
   Hap3: GCTTA |  |  |  |  |  |
Diabetes | 22/34 | 1.00 | 9/10 | 1.17 (0.30-4.51) | Â |
Without diabetes | 1.00 | 95/220 | 29/65 | 1.11 (0.57-2.14) | 0.94 |
   Hap4: GCTCA |  |  |  |  |  |
Diabetes | 22/36 | 1.00 | 9/8 | 1.91 (0.42-8.78) | Â |
Without diabetes | 93/217 | 1.00 | 31/68 | 1.12 (0.59-2.11) | 0.43 |
   Hap5: GTTCG |  |  |  |  |  |
Diabetes | 26/27 | 1.00 | 5/17 | 0.50 (0.12-2.09) | Â |
Without diabetes | 92/232 | 1.00 | 32/53 | 2.12 (1.13-3.99) | 0.01 |
   Hap6: GCTCG |  |  |  |  |  |
Diabetes | 26/39 | 1.00 | 5/5 | 2.50 (0.32-19.61) | Â |
Without diabetes | 111/234 | 1.00 | 13/51 | 0.48 (0.21-1.10) | 0.06 |
   Hap7: TCTCG |  |  |  |  |  |
Diabetes | 25/41 | 1.00 | 6/3 | 7.15 (0.55-93.39) | Â |
Without diabetes | 1.00 | 109/257 | 14/28 | 1.10 (0.48-2.54) | 0.23 |
ApoE ε 4 carriers |  |  |  | ||
   Hap1: GCGCG |  |  |  |  |  |
Diabetes | 7/3 | 1.00 | 9/3 | 2.53 (0.19-33.57) | Â |
Without diabetes | 52/25 | 1.00 | 39/24 | 0.64 (0.28-1.48) | 0.71 |
   Hap2: GCTTG |  |  |  |  |  |
Diabetes | 12/4 | 1.00 | 4/2 | 2.17 (0.13-35.20) | Â |
Without diabetes | 48/28 | 1.00 | 43/21 | 1.04 (0.42-2.57) | 0.82 |
   Hap3: GCTTA |  |  |  |  |  |
Diabetes | 15/6 | 1.00 | 1/0 | NA | Â |
Without diabetes | 72/40 | 1.00 | 19/9 | 1.43 (0.47-4.31) | NA |
   Hap4: GCTCA |  |  |  |  |  |
Diabetes | 9/5 | 1.00 | 7/1 | NA | Â |
Without diabetes | 70/41 | 1.00 | 21/8 | 1.49 (0.48-4.60) | NA |
   Hap5: GTTCG |  |  |  |  |  |
Diabetes | 13/4 | 1.00 | 3/2 | NA | Â |
Without diabetes | 80/44 | 1.00 | 11/5 | 1.48 (0.35-6.26) | NA |
   Hap6: GCTCG |  |  |  |  |  |
Diabetes | 13/4 | 1.00 | 3/2 | NA | Â |
Without diabetes | 66/41 | 1.00 | 25/8 | 2.42 (0.74-7.95) | NA |
   Hap7: TCTCG |  |  |  |  |  |
Diabetes | 12/5 | 1.00 | 4/1 | NA | Â |
Without diabetes | 82/39 | 1.00 | 9/10 | 0.53 (0.16-1.72) | NA |