In vitro studies of the influence of glutamatergic agonists on the Na+,K+-ATPase and K+-p-nitrophenylphosphatase activities in the hippocampus and frontal cortex of rats

Table 6 ATPases and p -NPPases activities in the hippocampus in the presence or absence of 1 mM of glutamatergic agonists

	K⁺- pNPPase (10 mM)	Mg²⁺-pNPPase (10 mM)	Na⁺,K⁺-ATPase (9 mM)	Mg²⁺-ATPase (9 mM)	Na⁺,K⁺-ATPase (2 mM)	Mg²⁺-ATPase (2 mM)
Control	140.8 ± 19.4	52.6 ± 4.5	286.6 ± 25.3	205.7 ± 25.9	146.7 ± 14.5	141.7 ± 14.5
Glutamate	143.2 ± 9.8	52.5 ± 3.3	271.2 ± 36	190.0 ± 14.5	136.2 ± 14.7	145.4 ± 18.1
Control	107.2 ± 7.6	54.9 ± 5.8	327.2 ± 22.1	211.8 ± 22.1	137.9 ± 12.1	149.4 ± 10.9
NMDA	109.3 ± 9.2	56.7 ± 3.3	320.3 ± 32.4	204.6 ± 16.1	125.5 ± 10	150.1 ± 4.9
Control	163.1 ± 15.2	49.7 ± 6	300.6 ± 18.5	192.0 ± 28.6	156.2 ± 12.7	153.3 ± 17.7
AMPA	159.5 ± 21.2	50.9 ± 3.3	304.7 ± 15.6	187.3 ± 8.9	155.3 ± 21	150.3 ± 15.4
Control	134.0 ± 11.6	52.5 ± 4.7	290.7 ± 15.6	191.9 ± 20.1	154.2 ± 18.8	149.6 ± 18.1
Kainate	134.8 ± 10.1	54.1 ± 1.6	276 ± 31.7	172.3 ± 13.2	137.3 ± 13	148.6 ± 13.6

Values are expressed as mean ± standard deviation (5 animals/group). ATPases activities are expressed in nmol of P_i/mg protein/min, and p-PNPPases activities are expressed in nmol of p-nitrophenol/mg protein/min. The concentrations of the substrates are shown in parentheses.

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