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Table 1 Patient characteristics at baseline

From: The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes

 

Diabetic Nephropathy

Normoalbuminuria

P-value

Patient characteristics

   

N (% male)

448 (60.9)

419 (54.4)

p = 0.02

Age (years)

42.2 ± 10.5

45.3 ± 11.5

p < 0.001

Duration of DM (years)

28.2 ± 8.7

27.8 ± 10.1

p = 0.025

BMI (kg/m2)

24.2 ± 3.3

24.1 ± 2.9

p = 0.7

Retinopathy (nil/simplex/proliferative)

7/135/306

151/159/109

p < 0.001

Antihypertensiva (no/yes)

95/308

351/68

p < 0.001

Smokers (%)

46

39

p = 0.05

Glycemic control

   

Blood glucose (mmol/l)

11.0 ± 5.4

9.4 ± 4.7

p < 0.001

HbA1c (%)

9.4 ± 1.5

8.4 ± 1.1

p < 0.001

Parameters of Nephropathy

   

UAE (mg/24 h)

593.1 (250.0-1519.5)

7.0 (4.0-12.0)

p < 0.001

Plasma creatinine (μmol/l)

102 (82.0-136.3)

79 (53-81)

p < 0.001

GFR (ml/min/1.73 m2)

66.1 ± 27.7

87.4 ± 14.9

p < 0.001

ESRD (%male)

24 (70.8)

0

p < 0.001

Systolic Blood Pressure (mm Hg)

144.3 ± 21.8

133.8 ± 18.6

p < 0.001

Diastolic Blood Pressure (mm Hg)

82.5 ± 12.2

76.1 ± 9.6

p < 0.001

  1. Data are presented as mean ± SD, median (interquartile range), or N (%). The study was performed according to the principles of the Declaration of Helsinki and approved by the ethical committee of Copenhagen County. All patients gave informed consent.